Rabeprazole is a Proton Pump Inhibitor (PPI) which inhibits H+/K+ ATPase enzyme therefore decreases acid production and offers fastest onset of action.
Levosulpiride is a prokinetic agent. It acts by inhibiting enteric Dopamine (D2) receptors and also acts as a 5-HT4 receptor agonist. It also inhibits D2 receptors at chemoreceptor trigger zone (CTZ) in the CNS and acts as an anti-emetic agent.
Levosulpiride acts on upper gut, middle gut and lower gut.