Cefpodoxime Proxetil is orally active prodrug of Cefpodoxime, which belongs to third generation cephalosporin antibiotics. Cefpodoxime is a bacterial cell wall synthesis inhibitor and active against most of the Gram positive and Gram negative aerobes and anaerobes. Ofloxacin is 2nd generation fluoroquinolone antibiotic, acts by inhibiting DNA replication by acting on bacterial DNA gyrase II and Topoisomerase IV enzymes. Ofloxacin is a broad spectrum antibiotic covering Gram positive, Gram negative and Atypical bacteria.