Dengue is transmitted by the Aedes aegypti mosquito which in recent decades has become a major public health problem. Symptoms typically begin three to fourteen days after infection. This may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Current evidence suggests that those with a history of dengue fever are at highest risk for dengue hemorrhagic fever or dengue shock syndrome. One of the clinical feature of dengue fever is the rapid fall in the platelet counts leading to deadly complications such as dengue hemorrhagic fever.